Born in Donetsk, Ukraine, Professor Krylov received her MSc from Moscow State University and her PhD from the Hebrew University in Jerusalem (1996). Following postdoctoral training at the University of California, Berkeley, she joined USC's chemistry department (1998).

Professor Krylov's research is focused on theoretical and computational quantum chemistry. She develops theoretical models and software for open-shell and electronically excited species, including metastable states. Using computational chemistry, Professor Krylov investigates the role of radicals and electronically excited species in combustion, solar energy, bioimaging, spectroscopy, and quantum information science.

Professor Krylov has received the Dirac Medal, the Theoretical Chemistry Award, Bessel Research Award, Mildred Dresselhaus Award, and Plyler Prize for Molecular Spectroscopy & Dynamics. She has also been recognized by Inaugural WiSE Architects of Enduring Change Award, Hanna Reisler Mentoring Award, and Melon Mentoring Award. She is a Fellow of the ACS, APS, and AAAS; an elected member of the International Academy of Quantum Molecular Science; a Board Member of WATOC; and Simons Foundation Fellow in Theoretical Physics. Professor Krylov is an associate editor of Physical Chemistry-Chemical Physics and of Wires Computational Molecular Science. She is the president of Q-Chem Inc., one of the world's leading quantum chemistry programs.